|
Symbol Name ID |
Nos3
nitric oxide synthase 3, endothelial cell MGI:97362 |
| * | Aspects of the system are reported to show a normal phenotype. |
| Darker colors indicate more annotations |
| Human Phenotypes | Leukocytosis |
Acute lymphoblastic leukemia |
T-cell acute lymphoblastic leukemias |
Acute myeloid leukemia |
Sinusitis |
Chronic sinusitis |
Abnormality of the spleen |
Splenic infarction |
Splenomegaly |
Hepatosplenomegaly |
Pancreatitis |
Iridocyclitis |
Epididymitis |
Erythema nodosum |
Osteomyelitis |
Recurrent pneumonia |
Asthma |
Nontuberculous mycobacterial pulmonary infection |
Recurrent infections |
Recurrent bacterial infections |
Recurrent Burkholderia cepacia infections |
Recurrent Haemophilus influenzae infections |
Recurrent Staphylococcus aureus infections |
Recurrent Aspergillus infections |
Recurrent respiratory infections |
Recurrent bronchopulmonary infections |
Recurrent lower respiratory tract infections |
| Disease(s) Associated with NOS3 | |||||||||||||||||||||||||||
| acute lymphoblastic leukemia | |||||||||||||||||||||||||||
| acute myeloid leukemia | |||||||||||||||||||||||||||
| asthma | |||||||||||||||||||||||||||
| Behcet's disease | |||||||||||||||||||||||||||
| cystic fibrosis | |||||||||||||||||||||||||||
| sickle cell anemia |
| Mouse Phenotypes | immune system phenotype |
enhanced leukocyte tethering or rolling |
abnormal leukocyte adhesion |
increased susceptibility to induced colitis |
enlarged spleen |
increased basophil cell number |
increased eosinophil cell number |
increased neutrophil cell number |
decreased lymphocyte cell number |
abnormal spleen morphology |
abnormal neutrophil physiology |
abnormal osteoclast physiology |
abnormal lymph node morphology |
enlarged lymph nodes |
increased inflammatory response |
kidney inflammation |
increased susceptibility to bacterial infection |
increased susceptibility to bacterial infection induced morbidity/mortality |
|
| Availability | Mouse Genotype | ||||||||||||||||||
| Nos3em1(IMPC)Mbp/Nos3em1(IMPC)Mbp | |||||||||||||||||||
| Nos3m1Btlr/Nos3m1Btlr | |||||||||||||||||||
| Nos3M2Btlr/Nos3M2Btlr | |||||||||||||||||||
| Nos3tm1Plh/Nos3tm1Plh | |||||||||||||||||||
| Nos3tm1Unc/Nos3tm1Unc | * | ||||||||||||||||||
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/16/2024 MGI 6.23 |
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